LARTREAT EU project: Computer, Experimental and Clinicalmodel of Three-Dimensional Plaque

Place: Large Lecture Room - CVC Affiliation: University of Kragujevac, Kragujevac, Serbia

Atherosclerosis is a progressive disease characterized by inflammation, monocyte-macrophage migration, and lipid accumulation in the vascular wall. Atherosclerosis isinitially characterized by endothelial dysfunction, which favors lipid and cell elements crossing inside blood vessel wall. In this study we developed three-dimensional model of plaque formation and development which we tested on few examples from our own experimental measurement on animals and patients. Firstly a model of plaque formation on the pig left anterior descending coronaryartery (LAD) is simulated numerically using a specific animal data obtainedfrom IVUS and histological recordings. Then some patient data from carotid and coronary artery were examined. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. A full three-dimensional model was created. It includes blood flow and LDL concentration, as well as plaque formation and progression. Matching of IVUS and histological animal data is performed using a 3D histological image reconstruction and 3D deformation of elasticbody. Our results for plaque localization correspond to low shear stress zone and we fitted parameters from our model using non linear leasts quare method.

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